Covishield vs Covaxin: Full Comparison, Efficacy Rate, Benefits, Side Effects

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Covishield vs Covaxin, the two vaccines used in the COVID-19 immunization campaign, are still being administered in India, although many people don’t know how they vary. People above 18 may now take life-saving injections as of April 1st, the start of the third phase.

Though individuals are now unable to choose which vaccination they get, the first phase results clearly show that both vaccines are safe and effective when administered in India. There have been 41.2 crore doses given so far. 8.55 million individuals, or 6.3% of the total population, have had all of their vaccinations.

Covishield vs Covaxin

Covishield vs Covaxin

Homegrown vaccinations Covaxin and Covishield have been the driving force behind India’s mass immunization campaigns. Covaxin is made, developed, and produced entirely in India, while Covishield is created by the Serum Institute of India, headquartered in Pune. However, some specific differences and advantages separate the two.

The Oxford-AstraZeneca vaccine, or Covishield, is the most widely utilized option in most countries. Vaccinations like Covaxin have emerged as some of the most effective and tolerable options to counter mutant strains. However, does the fact that they are different mean that one is superior to the other?

What goes into their Creation?

As a result of years of research and development, Covaxin is an inactivated vaccination that has been shown effective against dead viruses. This vaccine is produced from Whole-Virion Inactivated Vero Cells.

Although inactivated viruses cannot infect a person, they may educate the immune system to build a defense mechanism against a live virus. The viral vector platform on which Covishield was built is an entirely new kind of technology. Human cells may now be infected with the COVID-19 spike protein through a chimpanzee adenovirus called ChadOx1.

This cold virus can’t infect the recipient, but it can educate the immune system on how to defend itself against future infections better. Both vaccinations are given in two doses, one week apart. They may also be given intramuscularly, in the form of an injection into the muscles of the upper arm. Whereas the second dosage of Covaxin must be given 4-6 weeks after the first, the double dose of Covishield may be deferred and administered 6-8 weeks later.

Covishield vs Covaxin Efficacy

Both vaccines have been proven to be very successful in mapping efficacy, meeting WHO criteria, and eliciting significant immune responses. As of November of last year, Covishield had an effectiveness rate of 70% and may be scaled up to 90% if half the dose is given one month later, followed by the total dosage.

A recent study showed that tolerability and protection were also well-suited for reducing infection symptoms and speeding up recovery times, which has been widely discussed.

In February, Covaxin, an afterthought in the race, had finished significant testing. The Bharat Biotech vaccine, according to preliminary findings and clinical trials, has an effectiveness rate of above 78%.In addition, clinical data indicate that Covaxin may decrease the severity and mortality risk by 100%.

How well do they Defend Against Newly Discovered-Mutants?

New mutant forms of the virus have been discovered, making it much more lethal than previously. Newly discovered double and triple mutant strains in India have exacerbated fears raised by the UK Kent strain, Brazilian and South African songs, and South African tunes.

Covaxin is considerably more successful in controlling infectivity and demonstrating excellent resistance against newer, virulent strains, including the UK variant related to many instances. However, vaccinations aren’t the holy grail for eradicating the virus.

On the other hand, experts have noted that the only method to fight and prevent the spread of new mutant strains and variations is via vaccination with any accessible jab. People should thus be injected whenever possible.

Administrated Doses

There is no change in dose between the two shots. Both drugs are injected into the upper arm using a 0.5ml needle.
However, the timetable for administering both vaccinations differs. For Covaxin vaccinations, the second dosage is given 4-6 weeks after the first dose, while for Covishield vaccines, the double dose is given 84 days or 12-16 weeks after the first shot.

Covishield vs Covaxin Guidelines For Keeping Them Safe

As with most home refrigerators, temperatures between 2 and 8 degrees Celsius may be used to store both Covishield vs Covaxin. As most vaccinations in India are kept within the same temperature range, both vaccines are well-suited to the country’s climate.

Transport and storage of both vaccinations will be a lot less complicated now.


In India, both vaccinations had shown excellent outcomes when they were first introduced.

The Covishield vaccine has a worldwide efficacy rate of almost 90%, while interim 3rd phase trial data show that the Covaxin vaccine has a global effectiveness rate of 81%.


Limited emergency use of Covishield vs Covaxin for the prevention of coronavirus infection in people over the age of 18 has been authorized. The Covaxin clinical study has started in children over the age of two.

No vaccination has received approval for use on the Indian market from the Drugs Controller General of India (DGCI).


The vaccinations Covishield vs Covaxin are both administered intramuscularly.


Covishield vs Covaxin is safe for use in adults and adolescents over the age of eighteen.

Covishield vs Covaxin Side Effects

  • Both Covishield vs Covaxin have reactogenic adverse effects, much like the other vaccinations available. The majority of vaccine-related adverse effects are considered to be minor.
  • Tenderness, fever, chills, and nausea may all occur as a result of an injection. In a few instances, headache, stomach discomfort, dizziness, and tremors were also seen.
  • Many nations have called for a temporary stop to Covishield use after some users suffered blood clots after using the product.
  • There have been a few reports of neurological problems, although they are very uncommon.
    Complications with Covaxin have yet to be reported.

Which is Super in the End?

While both Covishield vs Covaxin has advantages and disadvantages, one is superior to the other. Both are equally safe to use, and the Drugs Controller General of India has only approved them after a thorough examination (DCGI).

The most important thing is to be protected against coronavirus, regardless of the vaccination used. Indian people also don’t choose which vaccination they get, as mandated by the country’s constitution.

So, regardless of Covishield vs Covaxin, the best course of action is to register and be vaccinated as soon as feasible.

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